This UK-based prospective observational longitudinal study examined fertility, time to pregnancy and pregnancy outcomes among people experiencing recurrent miscarriage. The researchers used real-world data from 1,201 couples attending National Health Service miscarriage clinics, including medical and obstetric history, investigation results, pregnancy outcomes and neonatal outcomes. Participants were recruited through NHS recurrent miscarriage clinics and had a history of previous miscarriages.
The study found that increased maternal age, higher BMI, polycystic ovary syndrome and a higher number of previous miscarriages were associated with reduced odds of a viable pregnancy. Increased maternal age, higher BMI and smoking were associated with a lower likelihood of conception, while folic acid supplementation and a history of previous conceptions were associated with increased fertility.
Authors: Aleksandra Koki, Pedro Melo, Adam J Devall, Rima Dhillon-Smith, Arri Coomarasamy
Publication date: 2 June 2025
Journal: The Lancet Regional Health – Europe, Volume 55, Article 101343
Link to paper: https://doi.org/10.1016/j.lanepe.2025.101343
